| Full text | |
| Author(s): |
Rocha, Lenilson C.
[1]
;
Ferreira, Hercules V.
[1]
;
Pimenta, Eli F.
[1]
;
Berlinck, Roberto G. S.
[1]
;
Seleghim, Mirna H. R.
[2]
;
Javaroti, Darci C. D.
[2]
;
Sette, Lara D.
[3]
;
Bonugli, Rafaella C.
[3]
;
Porto, Andre L. M.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Inst Quim Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Fed Sao Carlos, Dept Ecol & Biol Evolut, BR-13565905 Sao Carlos, SP - Brazil
[3] Univ Estadual Campinas, Div Recursos Microbianos, Ctr Pluridisciplinar Pesquisas Quim Biol & Agr, BR-13140000 Paulinia, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Biotechnology Letters; v. 31, n. 10, p. 1559-1563, OCT 2009. |
| Web of Science Citations: | 29 |
| Abstract | |
The asymmetric reduction of 2-chloro-1-phenylethanone (1) by seven strains of marine fungi was evaluated and afforded (S)-(-)-2-chloro-1-phenylethanol with, in the best case, an enantiomeric excess of 50% and an isolated yield of 60%. The ability of marine fungi to catalyse the reduction was directly dependent on growth in artificial sea water-based medium containing a high concentration of Cl(-) (1.2 M). When fungi were grown in the absence of artificial sea water, no reduction of 1 by whole cells was observed. The biocatalytic reduction of 1 was more efficient at neutral rather than acidic pH values and in the absence of glucose as co-substrate. (AU) | |
| FAPESP's process: | 05/60175-2 - Discovery and development of potential chemotherapeutic agents based on marine invertebrates and associated micro-organisms |
| Grantee: | Roberto Gomes de Souza Berlinck |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |