Plasmodium vivax circumsporozoite variants and Duffy blood group genotypes in the Brazilian Amazon region

Author(s):Show less -

Storti-Melo, Luciane M. ^{[1, 2]} ; de Souza-Neiras, Wanessa C. ^{[1, 2]} ; Cassiano, Gustavo C. ^{[1, 2]} ; Joazeiro, Ana C. P. ^[1] ; Fontes, Cor J. ^[3] ; Bonini-Domingos, Claudia R. ^[2] ; D'Almeida Couto, Alvaro A. R. ^[4] ; Povoa, Marinete M. ^[5] ; de Mattos, Luiz C. ^{[1, 2]} ; Cavasini, Carlos E. ^[1] ; Rossit, Andrea R. B. ^{[1, 2, 6]} ; Machado, Ricardo L. D. ^{[1, 2, 6]}

Affiliation

^[1] Fac Med Sao Jose do Rio Preto, Sao Jose Do Rio Preto, SP - Brazil

^[2] Univ Sao Paulo State Julio Mesquito Filho, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil

^[3] Univ Fed Mato Grosso, Dept Clin Med, BR-78048902 Cuiaba, Mato Grosso Sta - Brazil

^[4] SEAMA Fac, Macapa, Amapa State - Brazil

^[5] Evandro Chagas Inst, MS SVS, BR-67030000 Ananindeua, Para - Brazil

^[6] Sao Jose do Rio Preto Fdn, Fac Med, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil

• Document type: Journal article
• Source: Transactions of the Royal Society of Tropical Medicine and Hygiene; v. 103, n. 7, p. 672-678, JUL 2009.
• Web of Science Citations: 13

Abstract

The circumsporozoite protein (CSP) of the Plasmodium vivax infective sporozoite is considered to be a major target for the development of recombinant malaria vaccines. The Duffy blood group molecule acts as the red blood cell receptor for P vivax. We review the frequency of P vivax CSP variants and report their association with the Duffy blood group genotypes from Brazilian Amazon patients carrying P vivax malaria. Peripheral blood samples were collected from 155 P vivax-infected individuals from five Brazilian malaria-endemic areas. The P vivax CSP variants and the Duffy blood group genotypes were assessed using PCR/RFLP. In single infections, the VK210 variant was the commonest followed by the P vivax-like variant. The typing of P vivax indicated that the frequency of variants among the study areas was significantly different from one to another. This is the first detection of the VK247 and P vivax-like variant in single infections in endemic areas of Brazil. Association of the CSP P. vivax variants with the heterozygous Duffy blood group system genotype was significant for VK210 single infection. These observations provide additional data on the Plasmodium-host interactions concerning the Duffy blood group and P vivax capability of causing human malaria. (C) 2008 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 06/00982-4 - Molecular markers of the P. vivax associates the genotypes of the circumsporozoite protein
• Grantee: Ricardo Luiz Dantas Machado
• Support Opportunities: Regular Research Grants