| Full text | |
| Author(s): |
da Silva, Vanessa Vitoriano
[1]
;
Ropke, Cristina Dislich
[1]
;
Miranda, Denise Varella
[1]
;
de Almeida, Rebeca Leite
[1]
;
Higashi Sawada, Tania Cristina
[1]
;
Rivelli, Diogo Pineda
[1]
;
de Moraes Barros, Silvia Berlanga
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Fac Ciencias Farmaceut, Dept Anal Clin & Toxicol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | CUTANEOUS AND OCULAR TOXICOLOGY; v. 28, n. 2, p. 54-60, JUN 2009. |
| Web of Science Citations: | 3 |
| Abstract | |
In this study we assessed the protective effect of topical application of Pothomorphe umbellata extract on ultraviolet B (UVB)-induced skin lesion parameters in hairless mouse epidermis. A single dose of UVB irradiation (0.23 kJ/m(2)) resulted in a significant decrease in thymine dimer-positive cells and apoptotic sunburn cells, with an increase in p53 and proliferating cell nuclear antigen-positive cells in the epidermis. After 5 weeks (total dose 13.17 kJ/m(2)) and 15 weeks (total dose 55.51 kJ/m(2)) of irradiation, P. umbellata treatment inhibited the hyperplasic response and induced an increase in p53-positive cells. These findings suggest that P. umbellata extract affords protection against UVB-induced skin lesions. (AU) | |