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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Pathogenic and opportunistic respiratory bacteria-induced apoptosis

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Author(s):
Lancellotti, Marcelo [1] ; Carneiro Pereira, Rafaella Fabiana [1] ; Cury, Gisele Gentile [1] ; de Hollanda, Luciana Maria [2]
Total Authors: 4
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Biochem, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Biol, Dept Microbiol & Immunol, Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Journal of Infectious Diseases; v. 13, n. 3, p. 226-231, JUN 2009.
Web of Science Citations: 10
Abstract

Several pathogenic or opportunistic bacteria have the ability to either induce or inhibit host cell apoptosis. The capacity to modulate cell pathways that result in the induction or delay of host cell apoptosis is considered to be an important bacterial virulence mechanism. These processes could be mediated by different host cell signaling pathways that are subverted by the bacteria. Pathogens are able to activate apoptotic proteins, such as caspases, or inactivate anti-apoptotic proteins, such as NFkB and the MAPKKs, or even up-regulate the endogenous receptor/ligand system that induces apoptosis, generally when the bacteria are bound to the host cell surface. The bacteria-induced apoptotic or anti-apoptotic processes are often related with the fact that the bacteria acquire the ability to reach the host tissues. However, apoptosis is also considered to be a host defense mechanism against infectious agents. Thus, the apoptosis phenomenon plays a central role in host-pathogen interactions. (AU)