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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cytogenetic findings in an epithelioid sarcoma with angiomatoid features. A case report

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Author(s):
Brassesco, M. S. [1] ; Valera, E. T. [1] ; Castro-Gamero, A. M. [2] ; Moreno, D. A. [2] ; Silveira, T. P. [3] ; Mori, B. M. [1] ; Engel, E. E. [4] ; Scrideli, C. A. [1] ; Tone, L. G. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Puericultura & Pediat, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Genet, Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Patol, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Fac Med Ribeirao Preto, Div Ortoped & Traumatol, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Genetics and Molecular Research; v. 8, n. 4, p. 1211-1217, 2009.
Web of Science Citations: 3
Abstract

Epithelioid sarcoma is a rare, aggressive soft tissue tumor of unknown histogenesis showing predominantly epithelioid cytomorphology. We conducted a conventional and molecular cytogenetic study of a 27-year-old male with epithelioid sarcoma with angiomatoid features. Cytogenetic analysis of epithelioid sarcoma metaphase spreads by GTG-banding revealed a diploid chromosome complement with structural and numerical aberrations. Comparative genomic hybridization analysis demonstrated the amplification of 3p24 similar to pter, 4p15.2-p16 and 18q23, while chromosome losses involved 3p13-p14, 3q24-q26.1, 9q21, and 11q21. Fluorescence in situ hybridization assessment showed normal hybridization patterns for the C-MYC and CCND1 loci; CCND1 RNA overexpression was detected by real-time polymerase chain reaction analysis. Genetic evaluation of this rare condition may be useful in determining if epithelioid sarcoma is associated with a distinct genetic background. (AU)

FAPESP's process: 06/04827-3 - Analysis of aneuploidies by comparative genomic hybridization (CGH) in pediatric patients with acute lymphoid leukemia
Grantee:María Sol Brassesco Annichini
Support Opportunities: Scholarships in Brazil - Post-Doctoral