| Full text | |
| Author(s): |
Oliveira, Bruno L.
;
Cavalcanti, Clara M.
;
Azevedo, Ana Paula S.
;
Tomiyoshi, Marcio Y.
;
Bergami-Santos, Patricia C.
;
Barbuto, Jose Alexandre M.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Dept Immunol, Inst Ciencias Biomed, Lab Tumor Immunol, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | Cellular Immunology; v. 258, n. 1, p. 107-114, 2009. |
| Web of Science Citations: | 2 |
| Abstract | |
Dendritic cells (DCs), in peripheral tissues, derive mostly from blood precursors that differentiate into DCs under the influence of the local microenvironment. Monocytes constitute the main known DC precursors in blood and their infiltration into tissues is up-regulated during inflammation. During this process, the local production of mediators, like prostaglandins (PGs), influence significantly DC differentiation and function. In the present paper we show that treatment of blood adherent mononuclear cells with 10 mu M indomethacin, a dose achieved in human therapeutic settings, causes monocytes' progressive death but does not affect DCs viability or cell surface phenotype. This resistance of DCs was observed both for cells differentiated in vitro from blood monocytes and for a population with DCs characteristics already present in blood. This phenomenon could affect the local balance of antigen-presenting cells, influence the induction and pattern of immune responses developed under the treatment with non-steroidal anti-inflammatory drugs and, therefore, deserves further investigation. (C) 2009 Elsevier Inc. All rights reserved. (AU) | |
| FAPESP's process: | 04/09956-0 - Functional modulation of dendritic cells in different pathophysiological conditions |
| Grantee: | Jose Alexandre Marzagão Barbuto |
| Support Opportunities: | Research Projects - Thematic Grants |