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Functional modulation of dendritic cells in different pathophysiological conditions

Grant number: 04/09956-0
Support type:Research Projects - Thematic Grants
Duration: January 01, 2005 - December 31, 2009
Field of knowledge:Biological Sciences - Immunology
Principal Investigator:Jose Alexandre Marzagão Barbuto
Grantee:Jose Alexandre Marzagão Barbuto
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated grant(s):09/09571-5 - Cell-cell fusion from natural history to molecular physics and medical applications, AR.EXT
Associated scholarship(s):09/02074-6 - Investigation of a possible immunossuppressive bias in monocyte-derived dendritic cells from cancer patients, BP.MS
09/06095-8 - Effect of lymphocyte's heat stress on the phenotype and function of lymphocyte-dendritic cells hybrids, BP.IC
08/11278-1 - Dendritic cells functional deficiency: is the NF-kB pathway involved?, BP.PD


Dendritic Cells (DCs) are the major antigen presenting cells and the possibility of their generation in vitro has renewed the interest in immunotherapy protocols. However, their study shows that they are functionally heterogeneous and under poorly defined control mechanisms. The unravelling of such mechanisms may allow DCs exploitation in more efficient immunotherapy protocols. Therefore, the aim of the present project is the study of human DCs differentiation in vitro. in seven sub-projects, evaluating their function and membrane phenotype, under the effect of periodontal bacteria, different temperatures, apoptotic cells, heat-shock proteins, tumor cells, jaundice, hormones (specifically melatonin), and immunomodulatory drugs (specifically cyclophosphamide). (AU)

Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ROMAGNOLI, GRAZIELA GORETE; ZELANTE, BRUNA BARBOSA; TONIOLO, PATRICIA ARGENTA; MIGLIORI, ISABELLA KATZ; BARBUTO, JOSE ALEXANDRE M. Dendritic cell-derived exosomes may be a tool for cancer immunotherapy by converting tumor cells into immunogenic targets. FRONTIERS IN IMMUNOLOGY, v. 5, JAN 19 2015. Web of Science Citations: 41.
TOMIYOSHI, M. Y.; SAKAI, M.; BALEEIRO, R. B.; STANKEVICIUS, D.; MASSOCO, C. O.; PALERMO-NETO, J.; BARBUTO, J. A. M. Cohabitation with a B16F10 melanoma-bearer cage mate influences behavior and dendritic cell phenotype in mice. BRAIN BEHAVIOR AND IMMUNITY, v. 23, n. 4, p. 558-567, MAY 2009. Web of Science Citations: 13.
OLIVEIRA, BRUNO L.; CAVALCANTI, CLARA M.; AZEVEDO, ANA PAULA S.; TOMIYOSHI, MARCIO Y.; BERGAMI-SANTOS, PATRICIA C.; BARBUTO, JOSE ALEXANDRE M. Human monocytes but not dendritic cells are killed by blocking of autocrine cyclooxygenase activity. Cellular Immunology, v. 258, n. 1, p. 107-114, 2009. Web of Science Citations: 2.
BALEEIRO, R. B.; ANSELMO, L. B.; SOARES, F. A.; PINTO, C. A. L.; RAMOS, O.; GROSS, J. L.; HADDAD, F.; YOUNES, R. N.; TOMIYOSHI, M. Y.; BERGAMI-SANTOS, P. C.; BARBUTO, J. A. M. High frequency of immature dendritic cells and altered in situ production of interleukin-4 and tumor necrosis factor-ALPHA in lung cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY, v. 57, n. 9, p. 1335-1345, Sept. 2008.
BALEEIRO, R. B.; BERGAMI-SANTOS, P. C.; TOMIYOSHI, M. Y.; GROSS, J. L.; HADDAD, F.; PINTO, C. A. L.; SOARES, F. A.; YOUNES, R. N.; BARBUTO, J. A. M. Expression of a dendritic cell maturation marker CD83 on tumor cells from lung cancer patients and several human tumor cell lines: is there a biological meaning behind it?. CANCER IMMUNOLOGY IMMUNOTHERAPY, v. 57, n. 2, p. 265-270, Feb. 2008.
BALEEIRO‚ RB; BARBUTO‚ JAM. Local secretion/shedding of tumor-derived CD83 molecules as a novel tumor escape mechanism. Molecular Immunology, v. 45, n. 12, p. 3502-3504, 2008.

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