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Immunomodulatory effect of probiotic bacteria: analysis in peripheral monocytes and dendritic cells.

Grant number: 17/10829-3
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2017
Effective date (End): January 31, 2019
Field of knowledge:Health Sciences - Dentistry - Periodontology
Principal Investigator:Marcia Pinto Alves Mayer
Grantee:Gláuber Campos Vale
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:15/18273-9 - New strategies for the control of periodontitis, AP.TEM

Abstract

This proposal aims to establish fundamentals for the development of new strategies for periodontitis control. The general hypothesis to be tested is that the equilibrium in oral microbial-immune response relation, lost in periodontitis, could be recovered by favoring colonization of oral cavity by beneficial bacteria and modulation of immune response. The present project aims to determine the ability of probiotic strains to modulate the immune response in vitro and in animal models. Peripheral monocytes and dendritic cells will be used in co-culture assays with periodontal pathogens. The cytokine profile, expression of genes associated with the inflammatory process, activation of signaling pathways and functionality in the differentiation of T lymphocyte subtypes will be evaluated. This strategy aims to select probiotic strain(s) capable of inducing a response that changes the oral and intestinal microbiota favoring the health-associated microbiota, in balance with the host. These results will contribute to the establishment of capable strategies to interfering with the dysbiosis microbiota and host-response to the resident microbiota, favoring the maintenance of periodontal health.