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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biotransformation of a tetrahydrofuran lignan by the endophytic fungus Phomopsis Sp.

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Author(s):
Verza, Michelle [1] ; Arakawa, Nilton S. [1] ; Lopes, Norberto P. [1] ; Kato, Massuo J. [2] ; Pupo, Monica T. [1] ; Said, Suraia [1] ; Carvalho, Ivone [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-1404093 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Inst Quim, BR-05508900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 20, n. 1, p. 195-U243, 2009.
Web of Science Citations: 35
Abstract

The biotrasformation of the tetrahydrofuran lignan, (-)-grandisin, by the endophitic fungus Phomopsis sp, obtained from Viguiera arenaria, led to the formation of a new compound determined as 3,4-dimethyl-2-(4'-hydroxy-3',5'-dimethoxyphenyl)-5-methoxy-tetrahydrofuran. The metabolite was evaluated against the parasite Trypanosoma cruzi, the causative agent of Chagas's disease, and showed a trypanocidal activity (IC50 9.8 μmol L-1) similar to the natural precursor (IC50 3.7 μmol L-1). (AU)

FAPESP's process: 04/07935-6 - Bioprospection in fungi: the search of lead compounds for drug design and enzymes for pharmaceutical and industrial applications
Grantee:Jairo Kenupp Bastos
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants