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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Atomic force microscopy applied to immunoassays

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Author(s):
Antonio Aparecido Pupim Ferreira [1] ; Hideko Yamanaka [2]
Total Authors: 2
Affiliation:
[1] Universidade Estadual Paulista. Instituto de Química. Departamento de Bioquímica e Tecnologia Química - Brasil
[2] Universidade Estadual Paulista. Instituto de Química. Departamento de Química Analítica
Total Affiliations: 2
Document type: Journal article
Source: Química Nova; v. 29, n. 1, p. 137-142, 2006-02-00.
Field of knowledge: Physical Sciences and Mathematics - Chemistry
Abstract

Affinity reactions have been used for specific detection of their complementary partners and an enormous variety of enzyme-linked immunosorbent assay (ELISA) formats are used in research and in routine serological tests. With the advent of the atomic force microscopy (AFM) technique, the immune reactions have been monitored by these devices. In the present article we focus on applications of AFM to immunoassays. After introducing the basic concepts of AFM, a brief discussion on the monitoring of the interactions between antigens and antibodies through both topographic image and biosensor systems is presented. (AU)