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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Swimming training down-regulates plasma leptin levels, but not adipose tissue ob mRNA expression

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Author(s):
Benatti, F. B. [1] ; Polacow, V. O. [1] ; Ribeiro, S. M. L. [2] ; Gualano, B. [1] ; Coelho, D. F. [1] ; Rogeri, P. S. [1] ; Costa, A. S. [1] ; Lancha Junior, A. H. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Escola Educacao Fis & Esporte, Dept Biodinam, Sao Paulo - Brazil
[2] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Brazilian Journal of Medical and Biological Research; v. 41, n. 10, p. 866-871, OCT 2008.
Web of Science Citations: 6
Abstract

The aim of the present study was to assess the effects of endurance training on leptin levels and adipose tissue gene expression and their association with insulin, body composition and energy intake. Male Wistar rats were randomly divided into two groups: trained (N = 18) and sedentary controls (N = 20). The trained group underwent swimming training for 9 weeks. Leptin and insulin levels, adiposity and leptin gene expression in epididymal and inguinal adipose tissue were determined after training. There were no differences in energy intake between groups. Trained rats had a decreased final body weight (-10%), relative and total body fat (-36 and -55%, respectively) and insulin levels (-55%) compared with controls (P < 0.05). Although trained animals showed 56% lower leptin levels (2.58 ± 1.05 vs 5.89 ± 2.89 ng/mL in control; P < 0.05), no difference in leptin gene expression in either fat depot was demonstrable between groups. Stepwise multiple regression analysis showed that lower leptin levels in trained rats were due primarily to their lower body fat mass. After adjustment for total body fat, leptin levels were still 20% (P < 0.05) lower in exercised rats. In conclusion, nine weeks of swimming training did not affect leptin gene expression, but did lead to a decrease in leptin levels that was independent of changes in body fat. (AU)