| Full text | |
| Author(s): |
Marques, Alexandre F.
[1]
;
da Silva, Marcelo B.
[1]
;
Juliano, Maria A. P.
[2]
;
Munhoz, Julian E.
[1]
;
Travassos, Luiz R.
[3]
;
Taborda, Carlos P.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Dept Microbiol, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Microbes and Infection; v. 10, n. 12-13, p. 1251-1258, OCT 2008. |
| Web of Science Citations: | 34 |
| Abstract | |
Paracoccidioidomycosis is a systemic granulomatous disease manifested in the acute/subacute or chronic forms. The anergic cases of the acute/subacute form are most severe, leading to death threatening conditions. Drug treatment is required to control the disease but the response in anergic patients is generally poor. A 15-mer peptide from the major diagnostic antigen gp43, named P10, induces a T-CD4(+) helper-1 immune response in mice of different haplotypes and protects against intratracheal challenge with virulent P. brasiliensis. Presently, P10 immunization and chemotherapy were associated in an attempt to improve antifungal treatment in Balb/c mice made anergic by adding dexamethasone to the drinking water. The combined drug/peptide treatment significantly reduced the lung CFUs in infected anergic mice, largely preserved lung alveolar structure and prevented fungal dissemination to liver and spleen. Results recommend that a P10-based vaccine should be associated to chemotherapy for improved treatment of paracoccidioidomycosis aiming especially at anergic cases. (C) 2008 Elsevier Masson SAS. All rights reserved. (AU) | |
| FAPESP's process: | 06/50634-2 - Peptides and peptidases: biological activities in infectious diseases and cancer |
| Grantee: | Luiz Rodolpho Raja Gabaglia Travassos |
| Support Opportunities: | Research Projects - Thematic Grants |
| FAPESP's process: | 07/07588-2 - Efficacy and biological function of monoclonal antibodies against cell wall and exoantigens from Paracoccidioides brasiliensis |
| Grantee: | Carlos Pelleschi Taborda |
| Support Opportunities: | Regular Research Grants |