Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Crystal structure of the IL-22/IL-22R1 complex and its implications for the IL-22 signaling mechanism

Full text
Author(s):
Bleicher, Lucas [1] ; de Moura, Patricia Ribeiro [1] ; Watanabe, Leandra [1] ; Colau, Didier [2] ; Dumoutier, Laure [3, 2] ; Renauld, Jean-Christophe [3, 2] ; Polikarpov, Igor [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Carlos, SP - Brazil
[2] Ludwig Inst Canc Res, Brussels Branch, Brussels - Belgium
[3] Univ Catholique Louvain, Christian Duve Inst, Expt Med Unit, B-1200 Brussels - Belgium
Total Affiliations: 3
Document type: Journal article
Source: FEBS Letters; v. 582, n. 20, p. 2985-2992, SEP 3 2008.
Web of Science Citations: 58
Abstract

Interleukin-22 (IL-22) is a member of the interleukin-10 cytokine family, which is involved in anti-microbial defenses, tissue damage protection and repair, and acute phase responses. Its signaling mechanism involves the sequential binding of IL-22 to interleukin-22 receptor 1 (IL-22R1), and of this dimer to interleukin-10 receptor 2 (IL-10R2) extracellular domain. We report a 1.9 A crystal structure of the IL-22/IL-22R1 complex, revealing crucial interacting residues at the IL-22/IL-22R1 interface. Functional importance of key residues was confirmed by site-directed mutagenesis and functional studies. Based on the X-ray structure of the binary complex, we discuss a molecular basis of the IL-22/IL-22R1 recognition by IL-10R2. (AU)

FAPESP's process: 06/01534-5 - Studies of the interactions of thyroid hormone receptors with DNA and the coregulator proteins using X-ray crystallography
Grantee:Leandra Watanabe
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 06/00182-8 - Structural biophysics of nuclear receptors and related proteins
Grantee:Igor Polikarpov
Support Opportunities: Research Projects - Thematic Grants