| Full text | |
| Author(s): |
de Albuquerque Wobeto, Vania Peretti
[1]
;
Zaccariotto, Tania Regina
[1]
;
Sonati, Maria de Fatima
[1]
Total Authors: 3
|
| Affiliation: | [1] Univ Estadual Campinas, Fac Ciencias Med, Dept Patol Clin, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | GENETICS AND MOLECULAR BIOLOGY; v. 31, n. 3, p. 602-620, 2008. |
| Web of Science Citations: | 27 |
| Abstract | |
Haptoglobin (Hp) is a plasma glycoprotein, the main biological function of which is to bind free hemoglobin (Hb) and prevent the loss of iron and subsequent kidney damage following intravascular hemolysis. Haptoglobin is also a positive acute-phase protein with immunomodulatory properties. In humans, the HP locus is polymorphic, with two codominant alleles (HP1 and HP2) that yield three distinct genotypes/phenotypes (Hp1-1, Hp2-1 and Hp2-2). The corresponding proteins have structural and functional differences that may influence the susceptibility and/or outcome in several diseases. This article summarizes the available data on the structure and functions of Hp and the possible effects of Hp polymorphism in a number of important human disorders. (AU) | |
| FAPESP's process: | 05/02383-8 - Haptoglobin polymorphism and diabetic retinopathy |
| Grantee: | Maria de Fatima Sonati |
| Support Opportunities: | Regular Research Grants |