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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Haptoglobin genotypes in Chagas' disease

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Author(s):
Jorge, Susan E. D. C. [1] ; Abreu, Cristina Feix [1] ; Guariento, Maria Elena [2] ; Sonati, Maria de Fatima [1]
Total Authors: 4
Affiliation:
[1] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Med, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CLINICAL BIOCHEMISTRY; v. 43, n. 3, p. 314-316, FEB 2010.
Web of Science Citations: 7
Abstract

Objectives: To investigate the existence of an association between haptoglobin (Hp) genotypes and the severity of heart complications in Chagas' disease. Design and methods: Hp genotyping was performed by PCR in 107 Brazilian patients sub-classified in asymptomatic, with mild heart disease and with severe heart disease. Results: Multiple logistic regression (R(2) = 24%) indicated that patients with the Hp1-1 genotype have lower probability of developing the severe heart complications. Conclusion: The Hp polymorphism may influence the clinical evolution of Chagas' disease. (C) 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 08/01690-2 - Haptoglobin Genotypes in Sickle Cell Diseases
Grantee:Maria de Fatima Sonati
Support type: Regular Research Grants