Tetraploidization in Wilms tumor in an infant

Author(s)

Valera, E. T. ^[1] ; Brassesco, M. S. ^[1] ; Scrideli, C. A. ^[1] ; Tone, L. G. ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Puericultura & Pediat, Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Genetics and Molecular Research; v. 9, n. 3, p. 1577-1581, 2010.
• Web of Science Citations: 2

Abstract

Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones of tumor cells were observed, with DNA content varying from diploid to near-tetraploid complements. The genetic events involved in the acquisition of aneuploidy in Wilms tumor remain unclear. We hypothesize that initial tetraploidization caused aberrant cell division, leading to abnormal chromosomal segregation, cell transformation and tumorigenesis. (AU)

• FAPESP's process: 06/04827-3 - Analysis of aneuploidies by comparative genomic hybridization (CGH) in pediatric patients with acute lymphoid leukemia
• Grantee: María Sol Brassesco Annichini
• Support Opportunities: Scholarships in Brazil - Post-Doctoral