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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tetraploidization in Wilms tumor in an infant

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Author(s):
Valera, E. T. [1] ; Brassesco, M. S. [1] ; Scrideli, C. A. [1] ; Tone, L. G. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Puericultura & Pediat, Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Genetics and Molecular Research; v. 9, n. 3, p. 1577-1581, 2010.
Web of Science Citations: 2
Abstract

Genetic instability is frequent in human cancer. Unscheduled tetraploidization can trigger cell transformation and tumorigenesis. We made a cytogenetic analysis by Giemsa-trypsin banding of a stage I, biphasic Wilms tumor diagnosed in a 10-month-old male. An evident karyotypic heterogeneity was found. Four different subclones of tumor cells were observed, with DNA content varying from diploid to near-tetraploid complements. The genetic events involved in the acquisition of aneuploidy in Wilms tumor remain unclear. We hypothesize that initial tetraploidization caused aberrant cell division, leading to abnormal chromosomal segregation, cell transformation and tumorigenesis. (AU)