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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Chemical, spectroscopic characterization, and in vitro antibacterial studies of a new gold(I) complex with N-acetyl-L-cysteine

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Author(s):
Corbi, P. P. [1, 2] ; Quintao, F. A. [1] ; Ferraresi, D. K. D. [1] ; Lustri, W. R. [1] ; Amaral, A. C. [1] ; Massabni, A. C. [3]
Total Authors: 6
Affiliation:
[1] Ctr Univ Araraquara, Assoc Sao Bento Ensino, BR-14801320 Araraquara, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Lab Quim Bioinorgan & Med, Inst Quim, BR-13083970 Campinas, SP - Brazil
[3] UNESP, Dept Quim Geral & Inorgan, Inst Quim, BR-14801970 Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Coordination Chemistry; v. 63, n. 8, p. 1390-1397, 2010.
Web of Science Citations: 19
Abstract

A new gold(I) complex with N-acetyl-L-cysteine was synthesized and characterized by chemical and spectroscopic techniques. The elemental and thermal analyses of the solid compound fit to the composition AuC5H8NO3S center dot 0.75H2O. Solid-state 13C-nuclear magnetic resonance (SSNMR) and infrared (IR) analyses indicate the coordination of the ligand to Au(I) through sulfur. The insolubility of the complex in both polar and non-polar solvents supports a polymeric structure. The antibacterial activity of the complex was evaluated by antibiogram assays using the disc diffusion method. The compound showed effective antibacterial activity against Staphylococcus aureus (Gram positive) and Escherichia coli (Gram negative) bacterial cells. (AU)