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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro and in vivo determination of antioxidant activity and mode of action of isoquercitrin and Hyptis fasciculata

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Author(s):
Silva, C. G. [1, 2] ; Raulino, R. J. [1] ; Cerqueira, D. M. [3] ; Mannarino, S. C. [1] ; Pereira, M. D. [1] ; Panek, A. D. [1] ; Silva, J. F. M. [2] ; Menezes, F. S. [4] ; Eleutherio, E. C. A. [1]
Total Authors: 9
Affiliation:
[1] UFRJ, Dept Bioquim, Inst Quim, BR-21949900 Rio De Janeiro - Brazil
[2] UFRJ, Dept Quim Organ, Inst Quim, BR-21949900 Rio De Janeiro - Brazil
[3] UFRJ, ICB, Inst Biofis Carlos Chagas Filho, BR-21941590 Rio De Janeiro - Brazil
[4] Panoz Inst, Sch Pharm & Pharmaceut Sci, Dublin 2 - Ireland
Total Affiliations: 4
Document type: Journal article
Source: Phytomedicine; v. 16, n. 8, p. 761-767, AUG 2009.
Web of Science Citations: 35
Abstract

Reactive oxygen species (ROS) are thought to underline the process of ageing and the pathogenicity of various diseases, such as neurodegenerative disorders and cancer. The use of traditional medicine is widespread and plants still present a large source of natural antioxidants that might serve as leads for the development of novel drugs. In this paper, the alcoholic extract from leaves of Hyptis fasciculata, a Brazilian medicinal plant, and isoquercitrin, a flavonoid identified in this species, showed to be active as 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavengers. The extract of Hyptis fasciculata and isoquercitrin were also able to increase tolerance of the eukaryotic microorganism Saccharomyces cerevisiae to both hydrogen peroxide and menadione, a source of superoxide. Cellular protection was correlated with a decrease in oxidative stress markers, such as levels of ROS, protein carbonylation and lipid peroxidation, confirming the antioxidant potential of Hyptis fasciculata and isoquercitrin. (C) 2009 Elsevier GmbH. All rights reserved. (AU)

FAPESP's process: 04/10067-6 - Stress, transport and metabolism of alpha-glycosides in Saccharomyces cerevisiae
Grantee:Pedro Soares de Araujo
Support Opportunities: Research Projects - Thematic Grants