Reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells and diminished FOXP3 expression in patients with Common Variable Immunodeficiency: A link to autoimmunity?

Author(s)

Genre, J. ^[1] ; Errante, P. R. ; Kokron, C. M. ^{[2, 3]} ; Toledo-Barros, M. ^[2] ; Camara, N. O. S. ^[4] ; Rizzo, L. V. ^{[2, 3]}

Affiliation

^[1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, Lab Imunol Clin, BR-05508900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Div Clin Immunol & Allergy, Sch Med, BR-05508900 Sao Paulo - Brazil

^[3] Univ Sao Paulo, LIM 60, Sch Med, BR-05508900 Sao Paulo - Brazil

^[4] Univ Fed Sao Paulo, Div Nephrol, Sao Paulo - Brazil

• Document type: Journal article
• Source: Clinical Immunology; v. 132, n. 2, p. 215-221, AUG 2009.
• Web of Science Citations: 48

Abstract

Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disease characterized by defective immunoglobulin production and often associated with autoimmunity. We used flow cytometry to analyze CD4(+)CD25(HIGH)FOXP3(+) T regulatory (Treg) cells and ask whether perturbations in their frequency in peripheral blood could underlie the high incidence of autoimmune disorders in CVID patients. In this study, we report for the first time that CVID patients with autoimmune disease have a significantly reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells in their peripheral blood accompanied by a decreased intensity of FOXP3 expression. Notably, although CVID patients in whom autoimmunity was not diagnosed had a reduced frequency of CD4(+)CD25(HIGH)FOXP3(+) cells, FOXP3 expression levels did not differ from those in healthy controls. In conclusion, these data suggest compromised homeostasis of CD4(+)CD25(HIGH)FOXP3(+) cells in a subset of CVID patients with autoimmunity, and may implicate Treg cells in pathological mechanisms of CVID. (C) 2009 Elsevier Inc. All rights reserved. (AU)

• FAPESP's process: 07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models
• Grantee: Niels Olsen Saraiva Câmara
• Support Opportunities: Research Projects - Thematic Grants