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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Optical anisotropies in corneal stroma collagen fibers from diabetic spontaneous mice

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Author(s):
Aldrovani‚ M. ; Guaraldo‚ AMA ; Vidal‚ BC
Total Authors: 3
Document type: Journal article
Source: VISION RESEARCH; v. 47, n. 26, p. 3229-3237, 2007.
Abstract

In this work, optical retardation (OR) was investigated in corneal stroma collagen fibers from nonobese diabetic (NOD) and healthy (BALB/c) mice. Linear dichroism (LD) was investigated in corneas stained with Ponceau SS and Toluidine Blue, using microspectrophotometer. NOD corneas showed higher OR values than the control. Ponceau SS-complexed collagen fibers showed positive LD that was higher for NOD corneas. After staining with Toluidine Blue, NOD and BALB/c corneas showed negative LD. The results of this study demonstrate that diabetes was capable of altering the corneal optical anisotropies, possibly altering the number of intermolecular crosslinks in collagen fibers. (c) 2007 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 03/04597-0 - Molecular order and supramolecular organization of collagen bundles: differences in functionality, as a supposed effect of expression of pathogenesis, and methodological contribution
Grantee:Benedicto de Campos Vidal
Support Opportunities: Regular Research Grants