Natural products from the ascidian Botrylloides giganteum, from the sponges Verongula gigantea, Ircinia felix, Cliona delitrix and from the nudibranch Tambja eliora, from the Brazilian coastline

Author(s):Show less -

Ana Claudia Granato ^[1] ; Jaine H. H. L. de Oliveira ^[2] ; Mirna H. R. Seleghim ^[3] ; Roberto G. S. Berlinck ^[4] ; Mario L. Macedo ^[5] ; Antonio G. Ferreira ^[6] ; Rosana M. da Rocha ^[7] ; Eduardo Hajdu ^[8] ; Solange Peixinho ^[9] ; Claudia O. Pessoa ^[10] ; Manoel O. Moraes ^[11] ; Bruno C. Cavalcanti ^[12]

Affiliation:Show less -

^[1] Universidade de São Paulo. Instituto de Química de São Carlos

^[2] Universidade de São Paulo. Instituto de Química de São Carlos

^[3] Universidade de São Paulo. Instituto de Química de São Carlos

^[4] Universidade de São Paulo. Instituto de Química de São Carlos

^[5] Instituto de Química de São Carlos. Departamento de Química

^[6] Instituto de Química de São Carlos. Departamento de Química

^[7] Universidade Federal do Paraná. Setor de Ciências Biológicas. Departamento de Zoologia

^[8] Universidade Federal do Rio de Janeiro. Museu Nacional

^[9] Universidade Federal da Bahia. Departamento de Biologia

^[10] Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia

^[11] Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia

^[12] Universidade Federal do Ceará. Departamento de Fisiologia e Farmacologia

• Document type: Journal article
• Source: Química Nova; v. 28, n. 2, p. 192-198, 2005-03-00.
• Field of knowledge: Physical Sciences and Mathematics - Chemistry

Abstract

Two new marine metabolites, 3Z, 6Z, 9Z-dodecatrien-1-ol (1) from the ascidian Botrylloides giganteum and 4H-pyran-2ol acetate from the sponge Ircinia felix (4) are herein reported. The known bromotyrosine compounds, 2-(3,5-dibromo-4-methoxyphenyl)-N,N,N-dimethylethanammonium (2) and 2,6-dibromo-4-(2-(trimethylammonium)ethyl)phenol (3), have been isolated from the sponge Verongula gigantea. Serotonin (5) is reported for the first time from the sponge Cliona delitrix, and tambjamines A (15) and D (16) isolated as their respective salts from the nudibranch Tambja eliora. Only tambjamine D presented cytotoxicity against CEM (IC50 12.2 µg/mL) and HL60 (IC50 13.2 µg/mL) human leukemya cells, MCF-7 breast cancer cells (IC50 13.2 µg/mL), colon HCT-8 cancer cells (IC50 10.1 µg/mL) and murine melanoma B16 cancer cells (IC50 6.7 µg/mL). (AU)

• FAPESP's process: 96/04316-5 - Renewable marine resources of São Paulo State coast. Porifera (Demospongiae) and Chordata (Tunicata): taxonomy, chemistry and pharmacology
• Grantee: José Carlos de Freitas
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 01/03095-5 - Natural products from marine invertebrates: potential chemotherapic anti-proliferative, antibiotic and against tropical diseases agents
• Grantee: Roberto Gomes de Souza Berlinck
• Support Opportunities: Research Projects - Thematic Grants