| Full text | |
| Author(s): |
Francisco, Welington
[1]
;
Pivatto, Marcos
[2, 1]
;
Danuello, Amanda
[2, 1]
;
Regasini, Luis O.
[1]
;
Baccini, Luciene R.
[1]
;
Young, Maria C. M.
[3]
;
Lopes, Norberto P.
[2]
;
Lopes, Joao L. C.
[2]
;
Bolzani, Vanderlan S.
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Estadual Paulista UNESP, Inst Quim, Dept Quim Organica, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, BR-14801970 Araraquara, SP - Brazil
[2] USP, Fac Ciencias Farmaceuticas Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Inst Bot IBt, Sec Fisiol & Bioquim Plantas, BR-01061970 Sao Paulo - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Natural Products; v. 75, n. 3, p. 408-413, MAR 2012. |
| Web of Science Citations: | 13 |
| Abstract | |
As part of an ongoing research project on Senna and Cassia species, five new pyridine alkaloids, namely, 12'-hydroxy-7'-multijuguinol (1), 12'-hydroxy-8'-multijuguinol (2), methyl multijuguinate (3), 7'-multijuguinol (4), and 8'-multijuguinol (5), were isolated from the leaves of Senna multijuga (syn. Cassia multijuga). Their structures were elucidated on the basis of spectroscopic data analysis. Mass spectrometry was used for confirmation of the positions of the hydroxy groups in the side-chains of 1, 2, 4, and 5. All compounds exhibited weak in vitro acetylcholinesterase inhibitory activity as compared with the standard compound physostigmine. (AU) | |
| FAPESP's process: | 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II |
| Grantee: | Vanderlan da Silva Bolzani |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |