Curcumin-loaded into PLGA nanoparticles

Author(s)

Luz, Priscilla P. ^[1] ; Magalhaes, Lizandra G. ^[1] ; Pereira, Ana Carolina ^[1] ; Cunha, Wilson R. ^[1] ; Rodrigues, Vanderlei ^[2] ; Andrade e Silva, Marcio L. ^[1]

Affiliation

^[1] Univ Franca, Grp Pesquisas Prod Nat, Nucleo Pesquisas Ciencias Exatas & Tecnol, BR-14404600 Franca, SP - Brazil

^[2] Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Bioquim & Imunol, BR-14049900 Ribeirao Preto, SP - Brazil

• Document type: Journal article
• Source: Parasitology Research; v. 110, n. 2, p. 593-598, FEB 2012.
• Web of Science Citations: 25

Abstract

The incorporation of the curcumin into poly(lactic-co-glycolic)acid (PLGA) nanospheres by the nanoprecipitation technique, the characterization of the nanoparticles and the schistosomicidal activity of the curcumin-loaded into PLGA nanospheres were reported. The incorporation process occurred with high efficiency and the images of field-emission scanning electron microscopy (FESEM) revealed the production of spherically shaped particles. According to the dynamic light scattering measurements, the particles are nanometric and monodisperse. The curcumin-loaded PLGA nanoparticles (50 and 100 mu M) caused the death of all worms and a separation between 50% and 100% of Schistosoma mansoni couples at concentrations from 30 mu M. Moreover, the curcumin-loaded PLGA nanoparticles also decreased the motor activity and caused partial alterations in the tegument of adult worms. This study marks the first time that schistosomicidal activity has been reported for curcumin-loaded PLGA nanoparticles. (AU)

• FAPESP's process: 09/05049-2 - Development of polymeric nanaparticles and biodegradable systems containing lignans and evaluation its Chagas disease and schistosomiasis activities in vitro and in vivo
• Grantee: Márcio Luís Andrade e Silva
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/15207-4 - Evaluation of the effect of lignans and neolignans on Schistosoma mansoni: a proteomic study
• Grantee: Lizandra Guidi Magalhães
• Support Opportunities: Scholarships in Brazil - Post-Doctoral