| Full text | |
| Author(s): |
Macchiaverni, P.
[1]
;
Arslanian, C.
[1]
;
Frazao, J. B.
[1]
;
Palmeira, P.
[2]
;
Russo, M.
[1]
;
Verhasselt, V.
[3]
;
Condino-Neto, A.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Lab Med Invest LIM 36, Sch Med, Dept Pediat, Hosp Clin, BR-05508000 Sao Paulo - Brazil
[3] Univ Nice Sophia Antipolis, INSERM, U924, Valbonne - France
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Scandinavian Journal of Immunology; v. 74, n. 6, p. 619-627, DEC 2011. |
| Web of Science Citations: | 13 |
| Abstract | |
There is strong evidence from animal models that placental and/or breast milk-mediated transfer of maternal allergen-specific IgG prevents allergic immune responses in the progeny. Both human and animal data also point to IgA as having an important regulatory role. In contrast, little is known about maternal transfer of IgG and IgA specific for respiratory allergens in humans. Dermatophagoides pteronyssinus (Der p) is an indoor allergen that is a major cause of asthma worldwide. We analysed maternal to child Der p-specific IgG and IgA transfer in a cohort of 77 paired maternal and child samples. We found Der p-specific IgG and its IgG1, IgG2 and IgG4 subclasses in all cord blood samples. Except for IgG1, cord levels were higher in newborns from atopic mothers (n = 29) compared to non-atopic mothers (n = 48). Der p-specific IgA was found in all colostrum samples and levels were independent of maternal atopic status. Notably, anti-Der p IgG was also found in colostrum and levels were higher in atopic mothers. We believe that our work is a critical first step in the identification of early factors that may impact asthma development and should guide the development of clinical studies that assess whether Der p-specific IgG and IgA protect children from allergy as demonstrated in animal models. (AU) | |
| FAPESP's process: | 08/51535-3 - Study of maternal antibodies response to D. pteronyssinus, B. tropicalis and T. putrescentiae mites, and their passive transfer through placenta and maternal colostrum |
| Grantee: | Patricia Macchiaverni |
| Support Opportunities: | Scholarships in Brazil - Doctorate |