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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Subtle Gray Matter Changes in Temporo-Parietal Cortex Associated with Cardiovascular Risk Factors

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Author(s):
de Toledo Ferraz Alves, Tania Correa [1, 2] ; Scazufca, Marcia [1] ; Squarzoni, Paula [1] ; de Souza Duran, Fabio Luiz [1] ; Tamashiro-Duran, Jaqueline Hatsuko [1] ; Vallada, Homero P. [1] ; Andrei, Anna ; Wajngarten, Mauricio [3] ; Menezes, Paulo R. [3, 4] ; Busatto, Geraldo F. [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Psychiat, BR-05508 Sao Paulo - Brazil
[2] ABC Reg Med Sch, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Cardiol Inst, Gen Hosp, BR-05508 Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Prevent Med, BR-05508 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 27, n. 3, p. 575-589, 2011.
Web of Science Citations: 11
Abstract

Vascular risk factors may play an important role in the pathophysiology of Alzheimer's disease (AD). While there is consistent evidence of gray matter (GM) abnormalities in earlier stages of AD, the presence of more subtle GM changes associated with vascular risk factors in the absence of clinically significant vascular events has been scarcely investigated. This study aimed to examine GM changes in elderly subjects with cardiovascular risk factors. We predicted that the presence of cardiovascular risk would be associated with GM abnormalities involving the temporal-parietal cortices and limbic structures. We recruited 248 dementia-free subjects, age range 66-75 years, from the population-based ``Sao Paulo Ageing and Health Study{''}, classified in accordance to their Framingham Coronary Heart Disease Risk (FCHDR) score to undergo an MRI scan. We performed an overall analysis of covariance, controlled to total GM and APOE4 status, to investigate the presence of regional GM abnormalities in association with FCHDR subgroups (high-risk, medium-risk, and low-risk), and followed by post hoc t-test. We also applied a co-relational design in order to investigate the presence of linear progression of the GM vulnerability in association with cardiovascular risk factor. Voxel-based morphometry showed that the presence of cardiovascular risk factors were associated with regional GM loss involving the temporal cortices bilaterally. Those results retained statistical significance after including APOE4 as a covariate of interest. We also observed that there was a negative correlation between FCHDR scores and rGM distribution in the parietal cortex. Subclinical cerebrovascular abnormalities involving GM loss may provide an important link between cardiovascular risk factors and AD. (AU)

FAPESP's process: 04/15336-5 - Brain abnormalities associated with cardiovascular risk factors: a population-based study using voxel-a-voxel morphometry by magnetic resonance and measures of glucose metabolism by positron-emission tomography
Grantee:Geraldo Busatto Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 04/12694-8 - Incidence of dementia and cognitive decline in low-income elderly in São Paulo: a cohort study
Grantee:Isabela Judith Martins Bensenor
Support Opportunities: Regular Research Grants