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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biological effects of environmentally relevant concentrations of the pharmaceutical Triclosan in the marine mussel Perna perna (Linnaeus, 1758)

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Author(s):
Cortez, Fernando Sanzi [1, 2] ; Seabra Pereira, Camilo Dias [2, 3] ; Santos, Aldo Ramos [2] ; Cesar, Augusto [2, 3] ; Choueri, Rodrigo Brasil [2, 3] ; Martini, Gisela de Assis [2] ; Bohrer-Morel, Maria Beatriz [1]
Total Authors: 7
Affiliation:
[1] IPEN CNEN SP, Inst Pesquisas Energet & Nucl, BR-05508000 Sao Paulo - Brazil
[2] Univ Santa Cecilia, Lab Ecotoxicol, BR-11045907 Santos, SP - Brazil
[3] Univ Fed Sao Paulo, Inst Mar, BR-11030400 Santos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Environmental Pollution; v. 168, p. 145-150, SEP 2012.
Web of Science Citations: 36
Abstract

Triclosan (5-Chloro-2-(2,4-dichlorophenoxy) phenol) is an antibacterial compound widely employed in pharmaceuticals and personal care products. Although this emerging compound has been detected in aquatic environments, scarce information is found on the effects of Triclosan to marine organisms. The aim of this study was to evaluate the toxicity of a concentration range of Triclosan through fertilization assay (reproductive success), embryo-larval development assay (early life stage) and physiological stress (Neutral Red Retention Time assay - NRRT) (adult stage) in the marine sentinel organism Perna perm The mean inhibition concentrations for fertilization (IC50 = 0.490 mg L-1) and embryo-larval development (IC50 = 0.135 mg L-1) tests were above environmental relevant concentrations (ng L-1) given by previous studies. Differently, significant reduction on NRRT results was found at 12 ng L-1, demonstrating the current risk of the continuous introduction of Triclosan into aquatic environments, and the need of ecotoxicological studies oriented by the mechanism of action of the compound. (c) 2012 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/05121-2 - Effects of environmental concentrations of the drug Triclosan in the integrity of lysosomal membrane of Perna perna (Linnaeus, 1758) mussels
Grantee:Gisela de Assis Martini
Support Opportunities: Scholarships in Brazil - Scientific Initiation