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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oxidative stress markers and apoptosis in the prostate of diabetic rats and the influence of vitamin C treatment

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Author(s):
Gobbo, Marina Guimaraes [1, 2] ; Ribeiro, Daniele Lisboa [3] ; Taboga, Sebastiao Roberto [2] ; de Almeida, Eduardo Alves [4] ; Goes, Rejane Maira [2]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Inst Biol, Dept Cell Biol, Campinas, SP - Brazil
[2] Univ Estadual Paulisto UNESP, Inst Biosci Humanities & Exact Sci, Dept Biol, Sao Paulo - Brazil
[3] Fed Univ Uberlandia UFU, Inst Biomed Sci, Histol Sect, Uberlandia, MG - Brazil
[4] Univ Estadual Paulista UNESP, Inst Biosci Languages & Exact Sci, Dept Chem & Environm Sci, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Cellular Biochemistry; v. 113, n. 7, p. 2223-2233, JUL 2012.
Web of Science Citations: 11
Abstract

Negative consequences of diabetes on the prostate such as involution are associated with diminished testosterone, insulin deficiency, and hyperglycemia. The contributions of oxidative damage, which usually increases with diabetes, are unknown for these alterations. This study evaluated the impact of streptozotocin-induced diabetes on the biomarkers of the antioxidant system of rat ventral prostate, the influence of vitamin C supplementation on these biomarkers, and on the balance between cell proliferation and death. Diabetes (D) was induced in Wistar male rats by streptozotocin (5?mg/100?g b.w., i.p.). Control animals (C) were injected with a vehicle. Vitamin C (150?mg/kg b.w./day) supplementation was introduced by gavage in diabetes (D?+?V) as well as control (C?+?V) groups. Thirty days after diabetes onset, the rats were killed and the ventral prostates were analyzed using light microscopy, immunocytochemistry, and biochemical assays for biomarkers of oxidative stress. In comparison to control groups, the levels of circulating testosterone, proliferating, and androgen receptor-positive cells decreased in diabetic groups regardless of vitamin C treatment whereas apoptosis was increased. The levels of superoxide dismutase and glutathione peroxidase did not change, but the levels of glutathione-S-transferase (GST) were increased in diabetic prostate. Vitamin C supplementation normalized GST activity and recovered the apoptotic rates in the prostate. In conclusion, GST is a good indicator of compensatory oxidant defense in the prostate at earlier stages of diabetes and vitamin C improves its activity and attenuates apoptosis in the gland. J. Cell. Biochem. 113: 22232233, 2012. (c) 2012 Wiley Periodicals, Inc. (AU)

FAPESP's process: 08/05341-2 - REPERCUSSIONS OF THE OBESITY IN THE RAT VENTRAL PROSTATE: HISTOLOGICAL CHARACTERIZATION AND ANALYSIS OF ESTROGEN ROLE
Grantee:Rejane Maira Góes
Support Opportunities: Regular Research Grants
FAPESP's process: 08/00542-0 - REPERCUSSIONS OF THE OBESITY IN THE RAT VENTRAL PROSTATE: HISTOLOGICAL CHARACTERIZATION AND ANALYSIS OF THE ESTROGEN ROLE
Grantee:Daniele Lisboa Ribeiro
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 09/06885-9 - Influence of hyperglicemia and oxidative stress in kinetics of cell proliferation and death of acinar epithelium in the diabetic rat prostate.
Grantee:Marina Guimarães Gobbo
Support Opportunities: Scholarships in Brazil - Master