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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Characterization of two vasoactive peptides isolated from the plasma of the snake Crotalus durissus terrificus

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Author(s):
Barreto, S. A. [1] ; Chaguri, L. C. A. G. [1] ; Prezoto, B. C. [2] ; Lebrun, I. [1]
Total Authors: 4
Affiliation:
[1] Butantan Inst, Biochem & Biophys Lab, BR-05503900 Sao Paulo - Brazil
[2] Butantan Inst, Pharmacol Lab, BR-05503900 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: BIOMEDICINE & PHARMACOTHERAPY; v. 66, n. 4, p. 256-265, JUN 2012.
Web of Science Citations: 4
Abstract

Incubation of plasma from the snake Crotalus durissus terrificus (CDTP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for two sequences as: (Ser - Ile - Pro - Gln - Ala - Pro - Thr - Ser - Asn - Leu - Ile - Glu - Ala - Thr - Lys) and (Lys - Pro - Asp - Ala Asn - Gln - Val - Leu - Ile - Gln - Val - Ile - Gly - Val). These peptides display homology with fragments of albumin from Trimeresurus flavoviridis. Bolus intra-arterial injection of the purified or the synthetic peptide produced a strong and sustained vasopressor response in the anaesthetized snake (CDT) and rats (Wistar); this hypotensive effect was also potentiated by captopril-an angiotensin-converting (0.1 mg/kg) enzyme inhibitor. (C) 2012 Elsevier Masson SAS. All rights reserved. (AU)