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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Conventional and Doppler ultrasound for the differentiation of benign and malignant canine mammary tumours

Full text
Author(s):
Feliciano, M. A. R. [1] ; Vicente, W. R. R. [1] ; Silva, M. A. M. [1]
Total Authors: 3
Affiliation:
[1] Sao Paulo State Univ UNESP, Dept Anim Reprod, Coll Agr & Vet Sci, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: JOURNAL OF SMALL ANIMAL PRACTICE; v. 53, n. 6, p. 332-337, JUN 2012.
Web of Science Citations: 22
Abstract

Objectives: The aim of this study was to evaluate the sensitivity of conventional and Doppler ultrasound for differentiation of benign and malignant mammary tumours in female dogs. Methods: Mammary tumours were evaluated from 60 animals and divided into two distinct groups, group 1 (benign tumours) and group 2 (malignant tumours). The tumours were assessed by conventional ultrasound, Doppler ultrasound mode, histopathology and immunohistochemical detection of vascular endothelial growth factor. Results: Conventional ultrasound examination was found to be ineffective in separating tumours into the two experimental groups. Similarly, using colour-flow Doppler ultrasound, no correlation was found between the presence of vascularisation and its characteristics between the two groups. Triplex Doppler ultrasound yielded average maximum velocities of 28.71 cm/s for malignant and 19.91 cm/s for benign tumours, which were significantly different (P=0.01). For vascular endothelial growth factor, an average score of 2.22 was found for group 2 and 1.66 for group 1 (P=0.03). Positive correlations were found between vascular endothelial growth factor and presence of vascularisation (P=0.04 and r=0.3658) and between vascular endothelial growth factor and maximum velocity (P=0.03 and r=0.3913). Clinical Significance: Doppler evaluation may be used to predict malignancy of mammary tumours in bitches. (AU)

FAPESP's process: 08/08180-0 - Conventional ultrasound and color-flow and Power Doppler for the evaluation of canine mammary tumors
Grantee:Marcus Antônio Rossi Feliciano
Support Opportunities: Scholarships in Brazil - Doctorate