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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Birth weight, current body mass index, and insulin sensitivity and secretion in young adults in two Latin American populations

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Author(s):
Silva, A. A. M. [1] ; Santos, C. J. N. [1] ; Amigo, H. [2] ; Barbieri, M. A. [3] ; Bustos, P. [2] ; Bettiol, H. [3] ; Rona, R. J. [4]
Total Authors: 7
Affiliation:
[1] Univ Fed Maranhao, Dept Publ Hlth, BR-65075630 Sao Luis - Brazil
[2] Univ Chile, Fac Med, Dept Nutr, Santiago 7 - Chile
[3] Univ Sao Paulo, Fac Med, Dept Puericulture & Pediat, BR-14049 Ribeirao Preto - Brazil
[4] Kings Coll London, Dept Psychol Med, Weston Educ Ctr, London - England
Total Affiliations: 4
Document type: Journal article
Source: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; v. 22, n. 6, p. 533-539, JUN 2012.
Web of Science Citations: 11
Abstract

Background and aims: Although studies have shown association of birth weight (BW) and adult body mass index (BMI) with insulin sensitivity in adults, there is limited evidence that BW is associated with insulin secretion. We assessed the associations between BW and current BMI with insulin sensitivity and secretion in young Latin American adults. Methods and results: Two birth cohorts, one from Ribeirao Preto, Brazil, based on 1984 participants aged 23-25 years, and another from Limache, Chile, based on 965 participants aged 22-28 years were studied. Weight and height at birth, and current fasting plasma glucose and insulin levels were measured. Insulin sensitivity (HOMA%S) and secretion (HOMA%beta) were estimated using the Homeostatic Model Assessment (HOMA2). Multiple linear regression analyses were carried out to test the associations between BW and adult BMI z-scores on log HOMA%S and log HOMA%beta. BW z-score was associated with HOMA%S in the two populations and HOMA%beta in Ribeirao Preto when adult BMI z-score was included in the model. BW z-score was associated with decreasing insulin secretion even without adjusting for adult BMI, but only in Ribeirao Preto. BMI z-score was associated with low HOMA%S and high HOMA%beta. No interactions between BW and BMI z-scores on insulin sensitivity were shown. Conclusions: This study supports the finding that BW may affect insulin sensitivity and secretion in young adults. The effect size of BW on insulin status is small in comparison to current BMI. (C) 2010 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 00/09508-7 - From perinatal health to health of the young adult: study of cohort born in 1978/79 in the hospitals of Ribeirão Preto, SP
Grantee:Marco Antonio Barbieri
Support Opportunities: Research Projects - Thematic Grants