Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The beta 2-Adrenoceptor Agonist Formoterol Improves Structural and Functional Regenerative Capacity of Skeletal Muscles From Aged Rat at the Early Stages of Postinjury

Full text
Author(s):
Conte, Talita C. [1] ; Silva, Lucila H. [1] ; Silva, Meiricris T. [1] ; Hirabara, Sandro M. [2] ; Oliveira, Antonio C. [3] ; Curi, Rui [4] ; Moriscot, Anselmo S. [5] ; Aoki, Marcelo S. [6] ; Miyabara, Elen H. [1]
Total Authors: 9
Affiliation:
[1] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, BR-05508000 Sao Paulo - Brazil
[2] Univ Cruzeiro Sul, Inst Phys Act Sci & Sports, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, BR-05508000 Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, BR-05508000 Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, BR-05508000 Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Arts Sci & Human, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES; v. 67, n. 5, p. 443-455, MAY 2012.
Web of Science Citations: 11
Abstract

Skeletal muscles from old rats fail to completely regenerate following injury. This study investigated whether pharmacological stimulation of beta 2-adrenoceptors in aged muscles following injury could improve their regenerative capacity, focusing on myofiber size recovery. Young and aged rats were treated with a subcutaneous injection of beta 2-adrenergic agonist formoterol (2 mu g/kg/d) up to 10 and 21 days after soleus muscle injury. Formoterol-treated muscles from old rats evaluated at 10 and 21 days postinjury showed reduced inflammation and connective tissue but a similar number of regenerating myofibers of greater caliber when compared with their injured controls. Formoterol minimized the decrease in tetanic force and increased protein synthesis and mammalian target of rapamycin phosphorylation in old muscles at 10 days postinjury. Our results suggest that formoterol improves structural and functional regenerative capacity of regenerating skeletal muscles from aged rats by increasing protein synthesis via mammalian target of rapamycin activation. Furthermore, formoterol may have therapeutic benefits in recovery following muscle damage in senescent individuals. (AU)

FAPESP's process: 09/53528-7 - Skeletal muscle plasticity after injury and atrophy: influence of heat shock proteins
Grantee:Elen Haruka Miyabara
Support Opportunities: Regular Research Grants
FAPESP's process: 09/17667-2 - Morfological and molecular skeletal muscle plasticity after injury: effect of high voltage electric stimulation and low potency lasertherapy
Grantee:Elen Haruka Miyabara
Support Opportunities: Regular Research Grants
FAPESP's process: 09/12593-0 - Effect of beta 2-adrenergic stimulation on attenuation of skeletal muscle regenerative deficit in old rats.
Grantee:Lucila Hernandes da Silva
Support Opportunities: Scholarships in Brazil - Master