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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Platelet-rich plasma in the treatment of Class II furcation defects: a histometrical study in dogs

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Author(s):
Suaid, Fabricia Ferreira ; Carvalho, Marcelo Diniz [1] ; Bovi Ambrosano, Glaucia Maria [2] ; Nociti Junior, Francisco Humberto ; Casati, Marcio Zaffalon ; Sallum, Enilson Antonio [3]
Total Authors: 6
Affiliation:
[1] State Univ Amazonas, Dept Prosthodont & Periodont, Div Periodont, Manaus Dent Sch, Manaus, Amazonas - Brazil
[2] Univ Estadual Campinas, Dept Community Dent, Div Biostat, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP - Brazil
[3] Univ Estadual Campinas, Fac Odontol Piracicaba, Dept Protese & Periodontia, UNICAMP, Div Periodont, Piracicaba Dent Sch, BR-13414903 Piracicaba, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Applied Oral Science; v. 20, n. 2, p. 162-169, MAR-APR 2012.
Web of Science Citations: 10
Abstract

OBJECTIVE: This study was designed to evaluate the potential adjunctive benefits of platelet-rich plasma (PRP) when used with guided-tissue regeneration (GTR) and bioactive glass (BG) in the treatment of Class II furcation lesions. MATERIAL AND METHODS: Bilateral Class II furcation lesions were surgically created and allowed to become chronic in the mandibular third premolars of 9 dogs. The defects were randomly assigned to: A) GTR+BG and B) GTR+BG+PRP. Similar defects were created in the maxillary third premolars and received the same treatments after 45 days. Dogs were sacrificed 90 days after the first treatment. The histometric parameters evaluated were: connective tissue adaptation, new cementum, new bone, mineralized bone area, non-mineralized bone area, and residual BG particle area. RESULTS: Data analysis showed a superior length of new cementum and a greater mineralized bone area for group B in both periods (p<0.05). The non-mineralized bone area was greater in the control group (p<0.05) in both periods. CONCLUSION: Within the limits of this study, it can be concluded that the use of PRP in the treatment of Class II furcation defects may enhance the amount of new cementum and provide a more mineralized bone in a shorter period of time. (AU)