Contactless conductivity biosensor in microchip containing folic acid as bioreceptor

Author(s)

Lima, Renato S. ^{[1, 2]} ; Piazzetta, Maria H. O. ^[3] ; Gobbi, Angelo L. ^[3] ; Rodrigues-Filho, Ubirajara P. ^[2] ; Nascente, Pedro A. P. ^[4] ; Coltro, Wendell K. T. ^{[5, 1]} ; Carrilho, Emanuel ^{[1, 2]}

Affiliation

^[1] Inst Nacl Ciencia & Tecnol Bioanalit, Campinas, SP - Brazil

^[2] Univ Fed Sao Paulo, Inst Quim Sao Carlos, Sao Carlos, SP - Brazil

^[3] Ctr Nacl Pesquisa Energia & Mat, Lab Nacl Nanotecnol, Campinas, SP - Brazil

^[4] Univ Fed Sao Carlos, Dept Mat Engn, BR-13560 Sao Carlos, SP - Brazil

^[5] Univ Fed Goias, Inst Quim, Goiania, Go - Brazil

• Document type: Journal article
• Source: LAB ON A CHIP; v. 12, n. 11, p. 1963-1966, 2012.
• Web of Science Citations: 19

Abstract

We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. The device presents relevant advantages such as direct determination-dismiss the use of redox mediators as in faradaic electrochemical techniques-and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication. (AU)

• FAPESP's process: 10/08559-9 - Ultrasensitive electrochemical microfluidic systems
• Grantee: Renato Sousa Lima
• Support Opportunities: Scholarships in Brazil - Doctorate
• FAPESP's process: 08/07597-4 - A microsystem containing contactless conductometric biosensor for analysis of the FR-± cancer biomarker
• Grantee: Renato Sousa Lima
• Support Opportunities: Scholarships in Brazil - Master