Cellular prion protein ablation impairs behavior as a function of age

Coitinho‚ A.S.; Roesler‚ R.; Martins‚ V.R.; Brentani‚ R.R.; Izquierdo‚ I.

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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cellular prion protein ablation impairs behavior as a function of age

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Author(s):	Coitinho‚ A.S. ; Roesler‚ R. ; Martins‚ V.R. ; Brentani‚ R.R. ; Izquierdo‚ I. Total Authors: 5
Document type:	Journal article
Source:	Neuroreport; v. 14, n. 10, p. 1375-1379, 2003.
Abstract
Cellular prion protein (PrPc) has been associated with some physiological functions in recent reports. Here we investigate behavioral parameters in 3- and 9-month-old mice lacking PrPc protein (Prnp(0/0)) and in rats after intrahippocampal administration of affinity purified anti-PrPc IgG (0.09 mug/side). No differences were observed between 3-month-old animals. However, 9-month-old Prnp(0/0) mice and rats infused with anti-PrPc antibody showed a clear impairment of short- and long-term memory retention of a step-down inhibitory avoidance task. A decreased locomotor activity during exploration of an open field was also observed. These results suggest that systems involved in memory formation become more susceptible to mechanisms that require PrPc between the ages of 3 and 9 months in both mice and rats. (AU)

FAPESP's process:	99/07124-8 - The role of celular prion protein in physiological and pathological processes
Grantee:	Vilma Regina Martins
Support Opportunities:	Research Projects - Thematic Grants

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