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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

LSD and 9,10-dihydro-LSD Analyses in Street Drug Blotter Samples via Easy Ambient Sonic-Spray Ionization MassSpectrometry (EASI-MS)

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Author(s):
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Romao, Wanderson [1, 2] ; Sabino, Bruno D. [3] ; Bueno, Maria Izabel M. S. [2] ; Vaz, Boniek G. [2] ; Junior, Amadeu C. [3] ; Maldaner, Adriano O. [4] ; de Castro, Eustaquio V. R. [1] ; Lordeiro, Rogerio A. [5, 6] ; Nascentes, Clesia C. [5] ; Eberlin, Marcos N. [2] ; Augusti, Rodinei [5]
Total Authors: 11
Affiliation:
[1] Univ Fed Espirito Santo, Dept Chem, BR-29075910 Vitoria, ES - Brazil
[2] State Univ Campinas UNICAMP, Inst Chem, ThoMSon Mass Spectrometry Lab, BR-13084971 Campinas, SP - Brazil
[3] Carlos Eboli Inst Criminalist, BR-20060050 Rio De Janeiro - Brazil
[4] Brazilian Fed Police, Minist Justice, INC, BR-70390145 Brasilia, DF - Brazil
[5] Univ Fed Minas Gerais, Dept Chem, BR-29075910 Belo Horizonte, MG - Brazil
[6] Inst Criminalist Civil Police Minas Gerais, BR-30180060 Belo Horizonte, MG - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF FORENSIC SCIENCES; v. 57, n. 5, p. 1307-1312, SEP 2012.
Web of Science Citations: 13
Abstract

Normally, the identification of the LSD drug is performed by forensic laboratories, using the Ehrlich spot test. However, this is a nonspecific analysis. Additionally, the Brazilian Federal Police has identified the presence of a new compound in seized blotters: 9,10-dihydro-LSD, an uncontrolled substance. In this work, easy ambient sonic-spray ionization mass spectrometry in the positive ion mode, EASI(+)-MS, was used to characterize LSD and 9,10-dihydro-LSD compositions directly from the surface of blotters. The presence of LSD in the seized blotter samples were also confirmed via high-performance liquid chromatography with ultraviolet detector. In a set of 41 blotters analyzed by EASI(+)-MS, 28 showed positive results for LSD, seven for 9,10-dihydro-LSD, and another six samples showed negative results for both LSD and 9,10-dihydro-LSD. The combination of thin layer chromatography with EASI-MS also demonstrated to be a relatively simple and powerful screening tool for forensic analysis of street drugs. (AU)

FAPESP's process: 09/07168-9 - New applications of mass spectrometry in Forensic Chemistry
Grantee:Wanderson Romão
Support Opportunities: Scholarships in Brazil - Doctorate