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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of annexin-A1 peptide treatment during lung inflammation induced by lipopolysaccharide

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Author(s):
da Cunha, Esther Emanuella [1] ; Oliani, Sonia Maria [1] ; Damazo, Amilcar Sabino [2]
Total Authors: 3
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biociencias Letras & Ciencias Exatas, Dept Biol, BR-15054000 Sao Jose Do Rio Preto, SP - Brazil
[2] Fed Univ Mato Grosso UFMT, Fac Med, Dept Basic Sci Hlth, BR-78060900 Mato Grosso, MT - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pulmonary Pharmacology & Therapeutics; v. 25, n. 4, p. 303-311, AUG 2012.
Web of Science Citations: 8
Abstract

Lung endotoxemia is characterized by neutrophil accumulation, increased vascular permeability and parenchymal injury. This can also affect the endogenous pathways that operate in the host to keep inflammation under control. Here, we demonstrate differential expression of annexin-A1 (AnxA1) protein in mice after the local or intraperitoneal administration of lipopolysaccharide (LPS; 1 mg/kg) in mice and the regulation of the endotoxemic inflammation after the pre-treatment with the AnxA1 peptidomimetic Ac2-26. The intranasal administration of LPS induced the leukocyte migration and cytokine release to the alveolar space, whereas the peritoneal administration of LPS generated a deregulated cellular and cytokine response, with a marked degree of leukocyte adhesion in the microcirculation. The peptide Ac2-26 pre-treatment inhibited the leukocyte migration and the pro-inflammatory cytokine release. Also, it induced the expression of endogenous AnxA1 and the antiinflammatory cytokine IL-10. In conclusion, our data obtained from endotoxemia induced by local or intraperitoneal LPS administration suggested that the molecular mechanisms induced by AnxAl peptidomimetic Ac2-26 lead to the regulation of leukocyte activation/migration and cytokine production induced by LPS. (C) 2012 Elsevier Ltd. All rights reserved. (AU)