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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In situ effect of sodium fluoride or titanium tetrafluoride varnish and solution on carious demineralization of enamel

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Author(s):
Comar, Livia P. [1] ; Wiegand, Annette [2] ; Moron, Bruna M. [1] ; Rios, Daniela [3] ; Buzalaf, Marilia A. R. [1] ; Buchalla, Wolfgang [2] ; Magalhaes, Ana C. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, BR-17012901 Bauru, SP - Brazil
[2] Univ Zurich, Clin Prevent Dent Periodontol & Cariol, Zurich - Switzerland
[3] Univ Sao Paulo, Bauru Sch Dent, Dept Paediat Dent Orthodont & Publ Hlth, BR-17012901 Bauru, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: European Journal of Oral Sciences; v. 120, n. 4, p. 342-348, AUG 2012.
Web of Science Citations: 30
Abstract

This study evaluated the effect of titanium tetrafluoride (TiF4) formulations on enamel carious demineralization in situ. Thirteen subjects took part in this cross-over, split-mouth, double-blind study performed in three phases of 14 d each. In each subject, two sound and two predemineralized specimens of bovine enamel were worn intra-orally and plaque accumulation was allowed. One sound and one predemineralized specimen in each subject was treated once with sodium fluoride (NaF) varnish or solution (Treatment A); TiF4 varnish or solution (Treatment B); or placebo varnish or no treatment (Treatment C). The initially sound enamel specimens were exposed to severe cariogenic challenge (20% sucrose, eight times daily for 5 min each time), whereas the predemineralized specimens were not. Eleven subjects were able to finish all experimental phases. The enamel alterations were quantified by surface hardness and transversal microradiography. Demineralization of previously sound enamel was reduced by all test formulations except for the NaF solution, while both TiF4 formulations were as effective as NaF varnish. For the predemineralized specimens, enamel surface hardness was increased only by TiF4 formulations, while subsurface mineral remineralization could not be seen in any group. Within the experimental protocol, TiF4 was able to decrease enamel demineralization to a similar degree as NaF varnish under severe cariogenic challenges, while only TiF4 formulations remineralized the enamel surface. (AU)

FAPESP's process: 09/06534-1 - Comparison of the effect of TiF4 and NaF, incorporated into varnish and solution, on the demineralization and remineralization of bovine dental enamel in situ
Grantee:Livia Picchi Comar
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/09296-1 - Comparison of the effect of TiF4 and NaF varnishes and solutions on enamel de- and remineralization in situ
Grantee:Ana Carolina Magalhães
Support Opportunities: Regular Research Grants