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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

In vitro study of antiviral activity of mycophenolic acid on Brazilian Orthobunyaviruses

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Livonesi, Márcia Cristina ; Sousa, Ricardo Luiz Moro de ; Figueiredo, Luiz Tadeu Moraes [3]
Total Authors: 3
Document type: Journal article
Source: Intervirology; v. 50, n. 3, p. 204-208, Apr. 2007.
Field of knowledge: Biological Sciences - Microbiology

Oropouche, Caraparu, Guama, Guaroa and Tacaiuma are ssRNA viruses that belong to the genus Orthobunyavirus and have been associated with human febrile illnesses and/or encephalitis. In this study, we evaluated the antiviral action of mycophenolic acid (MPA) on theseorthobunyaviruses to achieve a therapeutic agent to treat the diseases caused by these viruses. The in vitro antiviral evaluation to MPA was done by using plaque assay at different periods of treatment. Results showed that MPA at a concentration of 10 ug/ml has significant antiviral activity on Tacaiuma virus when treatment was initiated either 24 h before or 2 h after viral infection. Moreover, MPA has an inhibitory effect on Guama virus replication, but only when treatment was initiated before cell infection. Addition of guanosine in the culture reverted the inhibitory effect of MPA on Tacaiuma and Guama viruses, suggesting that the antiviral activity of this substance was via depletion of the intracellular guanosine pool. Our results suggest that MPA would not be a good therapeutic agent to treat the diseases caused by Oropouche, Caraparu, Guama, Guaroa, and Tacaiuma viruses. (AU)

FAPESP's process: 03/03682-3 - Study on Brazilian arboviruses and rodent related viruses
Grantee:Luiz Tadeu Moraes Figueiredo
Support type: Research Projects - Thematic Grants