Expression of a dendritic cell maturation marker CD83 on tumor cells from lung cancer patients and several human tumor cell lines: is there a biological meaning behind it?

Baleeiro, R. B.; Bergami-Santos, P. C.; Tomiyoshi, M. Y.; Gross, J. L.; Haddad, F.; Pinto, C. A. L.; Soares, F. A.; Younes, R. N.; Barbuto, J. A. M.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Expression of a dendritic cell maturation marker CD83 on tumor cells from lung cancer patients and several human tumor cell lines: is there a biological meaning behind it?

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Author(s):	Baleeiro, R. B. ; Bergami-Santos, P. C. ; Tomiyoshi, M. Y. ; Gross, J. L. ; Haddad, F. ; Pinto, C. A. L. ; Soares, F. A. ; Younes, R. N. ; Barbuto, J. A. M. ^[9] Total Authors: 9
Document type:	Journal article
Source:	CANCER IMMUNOLOGY IMMUNOTHERAPY; v. 57, n. 2, p. 265-270, Feb. 2008.
Field of knowledge:	Biological Sciences - Immunology
Abstract
The present paper shows, for the first time, the membrane expression of the dendritic cell maturation marker CD83 on tumor cells from lung cancer patients. CD83 was also detected on freshly cultured fibroblast-like cells from these tissues and on several adherent human tumor cell lines (lung adenocarcinomas P9, A459 and A549, melanomas A375 and C81-61, breast adenocarcinomas SKBR-3 and MCF-7 and colon carcinoma AR42-J), but not in the non-adherent MOT leukemia cell line. CD83 may have immunosuppressive properties and its expression by cancer cells could have a role in facilitating tumor growth. (AU)

FAPESP's process:	04/09956-0 - Functional modulation of dendritic cells in different pathophysiological conditions
Grantee:	Jose Alexandre Marzagão Barbuto
Support Opportunities:	Research Projects - Thematic Grants

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