Epicolactone - Natural Product Isolated from the Sugarcane Endophytic Fungus Epicoccum nigrum

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Author(s):	da Silva Araujo, Francisca Diana ^[1] ; de Lima Favaro, Leia Cecilia ^[2] ; Araujo, Welington Luiz ^[3] ; de Oliveira, Fabio Lazzarotto ^[1] ; Aparicio, Ricardo ^[1] ; Marsaioli, Anita Jocelyne ^[1] Total Authors: 6
Affiliation:	^[1] Univ Estadual Campinas, Inst Chem, BR-13084971 Campinas, SP - Brazil ^[2] Embrapa Agroenergia, Brazilian Agr Res Corp, Brasilia, DF - Brazil ^[3] Univ Sao Paulo, Inst Biomed Sci, Sao Paulo - Brazil Total Affiliations: 3
Document type:	Journal article
Source:	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2012, n. 27, p. 5225-5230, SEP 2012.
Web of Science Citations:	32
Abstract
The endophytic fungus Epicoccum nigrum was isolated from sugarcane and the bioguided fractionation of the ethyl acetate extract led to the isolation of epicolactone, mellein, and 4,5-dimethylresorcinol. Characterization of epicolactone by MS, NMR and X-ray crystallography revealed a new natural product with an unusual carbon skeleton. The production of this secondary metabolite decreased in mutants of Epicoccum nigrum transformed by Agrobacterium tumefaciens. Additionally, these mutants produced 4-hydroxymellein. (AU)

FAPESP's process:	10/08286-2 - Identification of genes from endophytic fungi Epicoccum purpurascens and Epicoccum sp. involved in the biosynthesis of antimicrobial compounds
Grantee:	Welington Luiz de Araújo
Support Opportunities:	Regular Research Grants