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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fhos encodes a Drosophila Formin-Like Protein participating in autophagic programmed cell death

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Author(s):
Anhezini, Lucas [1] ; Saita, Ana Paula [1] ; Costa, Mara S. A. [1] ; Pinheiro Ramos, Ricardo Guelerman [1] ; Simon, Claudio Roberto [2]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Med, Dept Cell & Mol Biol & Pathogen Bioagents, Sao Paulo - Brazil
[2] Univ Fed Triangulo Mineiro, Dept Biol Struct, BR-38025015 Uberaba, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: GENESIS; v. 50, n. 9, p. 672-684, SEP 2012.
Web of Science Citations: 6
Abstract

Larval tissues undergo programmed cell death (PCD) during Drosophila metamorphosis. PCD is triggered in a stage and tissue-specific fashion in response to ecdysone pulses. The understanding of how ecdysone induces the stage and tissue-specificity of cell death remains obscure. Several steroid-regulated primary response genes have been shown to act as key regulators of cellular responses to ecdysone by inducing a cascade of transcriptional regulation of late responsive genes. In this article, the authors identify Fhos as a gene that is required for Drosophila larval salivary gland destruction. Animals with a P-element mutation in Fhos possess persistent larval salivary glands, and precise excisions of this P-element insertion resulted in reversion of this salivary gland mutant phenotype. Fhos encodes the Drosophila homolog of mammalian Formin Fhos. Fhos is differentially transcribed during development and responds to ecdysone in a method that is similar to other cell death genes. Similarly to what has been shown for its mammalian counterpart, FHOS protein is translocated to the nucleus at later stages of cell death. Fhos mutants posses disrupted actin cytoskeleton dynamics in persistent salivary glands. Together, our data indicate that Fhos is a new ecdysone-regulated gene that is crucial for changes in the actin cytoskeleton during salivary gland elimination in Drosophila. genesis 50:672684, 2012. (c) 2012 Wiley Periodicals, Inc. (AU)