Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Protective effects of yacon (Smallanthus sonchifolius) intake on experimental colon carcinogenesis

Full text
Author(s):
de Moura, Nelci A. [1] ; Caetano, Brunno F. R. [2] ; Sivieri, Katia [3] ; Urbano, Luis H. [4] ; Cabello, Claudio [4] ; Rodrigues, Maria A. M. [5] ; Barbisan, Luis F. [2]
Total Authors: 7
Affiliation:
[1] UNESP Sao Paulo State Univ, Inst Biosci, Program Postgrad, Gen & Appl Biol Program, BR-18618970 Botucatu, SP - Brazil
[2] UNESP Sao Paulo State Univ, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP - Brazil
[3] UNESP Sao Paulo State Univ, Sch Pharmaceut Sci, Dept Food & Nutr, BR-14801902 Araraquara, SP - Brazil
[4] UNESP Sao Paulo State Univ, Sch Agron Sci, CERAT, BR-18610307 Botucatu, SP - Brazil
[5] UNESP Sao Paulo State Univ, Sch Med, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Food and Chemical Toxicology; v. 50, n. 8, p. 2902-2910, AUG 2012.
Web of Science Citations: 29
Abstract

Yacon (Smallanthus sonchifolius), a tuberous root native to the Andean region of South America, contains high concentration of fructans with potential for colon cancer prevention. This study investigated the potential beneficial of yacon intake on colon carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in male Wistar rats. After 4 weeks of DMH-initiation, groups were fed basal diet (Cl and G6) or basal diet containing dried extract of yacon root at 0.5% (G2), 1.0% (G3 and G5) or a synbiotic formulation (G4) (1.0% yacon plus Lactobacillus casei at 2.5 x 10(10) CFU per g diet) for 13 weeks. At week 20, a significant reduction in number and multiplicity of aberrant crypt foci (ACF) and in number of invasive adenocarcinomas was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4) (0.05 < p < 0.001). Tumor multiplicity (noninvasive plus invasive) was significantly lower in the group fed synbiotic formulation (p < 0.02). A significant reduction in cell proliferation in colonic crypts and tumors and short chain fatty acids (SCFA) caecal contents was observed in the groups orally treated with 1.0% yacon (G3) or the synbiotic formulation (G4). Therefore, the findings this study indicate that yacon and yacon plus L casei intake may reduce the development of chemically-induced colon cancer. (C) 2012 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 11/01126-2 - Yacon (Polymnia sonchifolia) and rat colon carcinogenesis: effects on incidence and subtypes of aberrant crypt foci and tumors positive for beta-catenin
Grantee:Brunno Felipe Ramos Caetano
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 09/12239-2 - Effects of yacon (Polymnia sonchifolia) intake on colon carcinogenesis process induced by 1,2- dimethylhydrazine in male Wistar rats
Grantee:Nelci Antunes de Moura
Support Opportunities: Scholarships in Brazil - Master