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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

CYBA C242T polymorphism is associated with obesity and diabetes mellitus in Brazilian hypertensive patients

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Author(s):
Schreiber, R. [1] ; Ferreira-Sae, M. C. [1] ; Tucunduva, A. C. [1] ; Mill, J. G. [2] ; Costa, Felipe O. [1] ; Krieger, J. E. [3] ; Franchini, K. G. [1] ; Pereira, A. C. [3] ; Nadruz, Jr., W. [1]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Dept Internal Med, BR-13081970 Campinas, SP - Brazil
[2] Univ Fed Espirito Santo, Vitoria - Brazil
[3] Univ Sao Paulo, Heart Inst InCor, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: DIABETIC MEDICINE; v. 29, n. 7, p. E55-E61, JUL 2012.
Web of Science Citations: 5
Abstract

Diabet. Med. 29, e55e61 (2012) Abstract Aims The CYBA C242T polymorphism has been associated with cardiovascular phenotypes such as hypertension and atherosclerosis, but available data are conflicting. This report investigated the impact of this variant on hypertension and metabolic determinants of cardiovascular risk in a large Brazilian sample. Methods We cross-sectionally evaluated 1856 subjects (826 normotensive subjects and 1030 hypertensive patients) by clinical history, anthropometry, laboratory analysis and genotyping of the CYBA C242T polymorphism. Results Genotype frequencies in the whole population were consistent with the HardyWeinberg equilibrium and genotype distributions were not different between hypertensive and normotensive subjects. Hypertensive patients with the CC genotype presented lower fasting plasma glucose levels (5.9 +/- 0.1 vs. 6.2 +/- 0.1 mmol/l, P = 0.020) and waist circumference (94.5 +/- 0.6 vs. 96.3 +/- 0.6 cm, P = 0.028) than CT + TT ones. Similarly, the prevalence of diabetes mellitus and obesity was also lower in hypertensive patients carrying the CC genotype (16% vs. 21%, P = 0.041; 36% vs. 43%, P = 0.029, respectively). In addition, multiple and logistic regression analysis demonstrated that the CYBA C242T polymorphism was associated with glucose levels, waist circumference, obesity and diabetes mellitus in hypertensive patients independently of potential confounders. Conversely, in normotensive subjects, no significant difference in studied variables was detected between the genotype groups. Conclusions These data suggest that the T allele of the CYBA C242T polymorphism may be used as a marker for adverse metabolic features in Brazilian subjects with systemic hypertension. (AU)

FAPESP's process: 10/16252-0 - Mechanisms related to increased cardiovascular risk in spinal cord injury subjects
Grantee:Wilson Nadruz Junior
Support type: Regular Research Grants