Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in Sao Paulo, Brazil

Mantovani, N. P.; Azevedo, R. G.; Rabelato, J. T.; Sanabani, S.; Diaz, R. S.; Komninakis, S. V.

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Analysis of Transmitted Resistance to Raltegravir and Selective Pressure among HIV-1-Infected Patients on a Failing HAART in Sao Paulo, Brazil

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Author(s):	Mantovani, N. P. ^[1] ; Azevedo, R. G. ^[1] ; Rabelato, J. T. ^[2] ; Sanabani, S. ^[3] ; Diaz, R. S. ^[1] ; Komninakis, S. V. ^[1] Total Authors: 6
Affiliation:	^[1] Fed Univ Sao Paulo UNIFESP, Div Infect Dis, Retrovirol Lab, Sao Paulo - Brazil ^[2] Lusiada Fdn Santos, Mol Biol Lab, Dept Med, Santos - Brazil ^[3] Univ Sao Paulo, Div Clin Immunol & Allergy, Sao Paulo - Brazil Total Affiliations: 3
Document type:	Journal article
Source:	Journal of Clinical Microbiology; v. 50, n. 6, p. 2122-2125, JUN 2012.
Web of Science Citations:	2
Abstract
We studied the presence of primary resistance to raltegravir (RAL), natural polymorphisms, and selection pressure on HIV-1 integrase. We found a high frequency of integrase polymorphisms related to the resistance to RAL and sequence stability. Further studies are needed to determine the importance of these polymorphisms to RAL resistance. (AU)

FAPESP's process:	09/05712-3 - Analysis of the integrase gene of the human of immunodeficiency vírus (HIV-1) in subjects in HAART failure to treatment and without Raltegravir
Grantee:	Shirley Cavalcante Vasconcelos
Support Opportunities:	Regular Research Grants

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