Sleep, epilepsy and translational research: What can we learn from the laboratory bench?

Author(s)

Matos, Gabriela ^[1] ; Tufik, Sergio ^[1] ; Scorza, Fulvio A. ; Cavalheiro, Esper A. ; Andersen, Monica L. ^[1]

Affiliation

^[1] Univ Fed Sao Paulo UNIFESP, Dept Psicobiol, Sao Paulo - Brazil

• Document type: Review article
• Source: PROGRESS IN NEUROBIOLOGY; v. 95, n. 3, p. 396-405, NOV 2011.
• Web of Science Citations: 20

Abstract

The relationship between sleep and epilepsy has been known since ancient times, and the modulating effects of both on each other have been widely described in clinical studies. However, the mechanisms of this correlation remain unclear. Translational research is essential for filling the gaps in our knowledge, and for developing better therapeutic approaches to improve the quality of life of epileptic patients. Excellent animal models of epilepsy are available for the investigation of various aspects of epilepsy, such as epileptogenesis and hippocampal sclerosis. These models also show an association between sleep and epilepsy, suggesting that they are suitable for translational research on this relationship. While some knowledge has been obtained from preclinical studies, the topic remains relatively unexplored. In terms of the role of sleep in modulating seizure susceptibility in epilepsy, animal sleep research is a major tool. In this review, we focus on the intricate relationship between sleep and epilepsy in the preclinical setting, using a translational science approach. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• FAPESP's process: 98/14303-3 - Center for Sleep Studies
• Grantee: Sergio Tufik
• Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 10/15110-8 - Sleep and sudden unexpected death in epilepsy: possible molecular basis?
• Grantee: Gabriela de Matos Barbosa Pimenta
• Support Opportunities: Scholarships in Brazil - Post-Doctoral