Creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients

Author(s)

Gualano, Bruno ^[1] ; Lugaresi, Rebeca ^[1] ; de Salles, Vitor Painelli ^[1] ; Carrenho Queiroz, Andreia Cristina ^[1] ; Artioli, Guilherme ^[1] ; Roschel, Hamilton ^[1] ; Otaduy, Maria Concepcion ^[2] ; Leite, Claudia da Costa ^[2] ; Lancha, Jr., Antonio Herbert ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, Sch Med, BR-05508030 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Div Radiol, Sch Med, BR-05508030 Sao Paulo - Brazil

• Document type: Journal article
• Source: APPLIED PHYSIOLOGY NUTRITION AND METABOLISM; v. 36, n. 5, p. 764-767, OCT 2011.
• Web of Science Citations: 3

Abstract

We examined whether creatine supplementation affects muscle carnosine content in type 2 diabetic patients. Subjects were randomly assigned to receive either creatine (5 g.day(-1)) or placebo in a double-blind fashion. At baseline and after 12 weeks, carnosine content was evaluated in gastrocnemius and soleus muscles by using a 1H-MRS technique. No changes were found in gastrocnemius (p = 0.81) and soleus (p = 0.85). We concluded that creatine supplementation does not augment muscle carnosine content in type 2 diabetic patients. (AU)

• FAPESP's process: 10/11221-0 - Artificial elevation of muscle buffering capacity: effects upon muscle performance and function and underlying mechanisms
• Grantee: Antonio Herbert Lancha Junior
• Support Opportunities: Regular Research Grants