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Acute effects of b-alanine intake on regulatory mechanisms of muscle carnosine content

Grant number: 19/06140-5
Support type:Scholarships in Brazil - Master
Effective date (Start): November 01, 2019
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Bryan Saunders
Grantee:Breno Duarte Costa
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition, AP.JP


Carnosine is a dipeptide with several physiological actions, especially its intracellular buffering capacity. It is synthesized in situ from the amino acids L-histidine and beta-alanine and the increase of intramuscular carnosine concentrations via beta-alanine supplementation is well known. However, the relationship between the acute response of proteins and genes related to carnosine metabolism following beta-alanine supplementation and their relationship to chronic changes in muscle carnosine content are not fully understood. Fifteen healthy, physically active men (weekly physical activity but not involved in a structured training program) aged 18-35 will undergo acute supplementation of 1600 mg of beta -alanine and chronic intake of 6400 mg / day for 4 weeks. Muscle samples will be collected before and after the supplementation period to evaluate expression, activity and the amount of proteins and genes related to carnosine. The analysis of these parameters will aid in the understanding of the metabolism of carnosine and in the determination of more individualized and efficient supplementation guidelines. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RIBEIRO, RAFAEL; DUARTE, BRENO; DA SILVA, ANDRE GUEDES; RAMOS, GUILHERME PASSOS; PICANCO, ANDREIA ROSSI; PENNA, EDUARDO MACEDO; COSWIG, VICTOR; BARBALHO, MATHEUS; GENTIL, PAULO; GUALANO, BRUNO; SAUNDERS, BRYAN. Short-Duration Beta-Alanine Supplementation Did Not Prevent the Detrimental Effects of an Intense Preparatory Period on Exercise Capacity in Top-Level Female Footballers. FRONTIERS IN NUTRITION, v. 7, APR 21 2020. Web of Science Citations: 0.

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