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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Age-Related Metabolic Profiles in Cognitively Healthy Elders: Results from a Voxel-Based [F-18]Fluorodeoxyglucose-Positron-Emission Tomography Study with Partial Volume Effects Correction

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Author(s):
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Curiati, P. K. [1] ; Tamashiro-Duran, J. H. [1] ; Duran, F. L. S. [1] ; Buchpiguel, C. A. [1] ; Squarzoni, P. [1] ; Romano, D. C. [1] ; Vallada, H. [1] ; Menezes, P. R. [2] ; Scazufca, M. [3] ; Busatto, G. F. [1] ; Alves, T. C. T. F. [1]
Total Authors: 11
Affiliation:
[1] Univ Sao Paulo, Sch Med, Neuroimaging Psychiat Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Prevent Med, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Psychiat, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AMERICAN JOURNAL OF NEURORADIOLOGY; v. 32, n. 3, p. 560-565, MAR 2011.
Web of Science Citations: 27
Abstract

BACKGROUND AND PURPOSE: Functional brain variability has been scarcely investigated in cognitively healthy elderly subjects, and it is currently debated whether previous findings of regional metabolic variability are artifacts associated with brain atrophy. The primary purpose of this study was to test whether there is regional cerebral age-related hypometabolism specifically in later stages of life. MATERIALS AND METHODS: MR imaging and FDG-PET data were acquired from 55 cognitively healthy elderly subjects, and voxel-based linear correlations between age and GM volume or regional cerebral metabolism were conducted by using SPM5 in images with and without correction for PVE. To investigate sex-specific differences in the pattern of brain aging, we repeated the above voxelwise calculations after dividing our sample by sex. RESULTS: Our analysis revealed 2 large clusters of age-related metabolic decrease in the overall sample, 1 in the left orbitofrontal cortex and the other in the right temporolimbic region, encompassing the hippocampus, the parahippocampal gyrus, and the amygdala. The division of our sample by sex revealed significant sex-specific age-related metabolic decrease in the left temporolimbic region of men and in the left dorsolateral frontal cortex of women. When we applied atrophy correction to our PET data, none of the above-mentioned correlations remained significant. CONCLUSIONS: Our findings suggest that age-related functional brain variability in cognitively healthy elderly individuals is largely secondary to the degree of regional brain atrophy, and the findings provide support to the notion that appropriate PVE correction is a key tool in neuroimaging investigations. (AU)

FAPESP's process: 04/15336-5 - Brain abnormalities associated with cardiovascular risk factors: a population-based study using voxel-a-voxel morphometry by magnetic resonance and measures of glucose metabolism by positron-emission tomography
Grantee:Geraldo Busatto Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 06/04405-1 - MRI age-related changes: gray and white matter measurements by voxel based morphometry in the elderly population
Grantee:Pedro Kallas Curiati
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 04/12694-8 - Incidence of dementia and cognitive decline in low-income elderly in São Paulo: a cohort study
Grantee:Isabela Judith Martins Bensenor
Support Opportunities: Regular Research Grants