Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leukemia, non-Hodgkin's lymphoma, and Wilms tumor in childhood: the role of birth weight

Full text
Author(s):
Rangel, Marina [1, 2] ; Cypriano, Monica [3] ; de Martino Lee, Maria Lucia [3] ; Vercillo Luisi, Flavio Augusto [3] ; Petrilli, Antonio Sergio [3] ; Louzada Strufaldi, Maria Wany [3] ; Pinho Franco, Maria do Carmo [1]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Sch Med, Div Nephrol, BR-04023900 Sao Paulo - Brazil
[2] Methodist Univ Sao Paulo, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Pediat, Sch Med, BR-04023900 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF PEDIATRICS; v. 169, n. 7, p. 875-881, JUL 2010.
Web of Science Citations: 20
Abstract

There is emerging evidence that higher birth weight is associated with increased risk of cancer, in particular childhood leukemia. The purpose of this paper is to study whether this correlation is also significant with other childhood cancer. For this, we conducted a case-control study including 410 childhood cancer patients and 1,575 matched controls to investigate birth weight as a risk factor for leukemia, Wilms tumor, and non-Hodgkin's lymphoma. The estimated risk for all cancers has been found to be statistically and significantly higher in birth weight of more than 4,000 g (odds ratio, 2.50 and 95% confidence intervals (CI), 1.72-3.63). For leukemia, the estimated risk was 1.86 (95% CI, 1.04-3.30), for non-Hodgkin lymphoma, 1.99 (95% CI, 1.08-3.69), and being more remarkable for Wilms tumor, 4.76 (95% CI, 2.73-8.28). Moreover, moderate increased risk of both leukemia and non-Hodgkin lymphoma was also associated with birth weight between 3,000 and 3,999 g. High birth weight was associated with all cancers also when adjusted by gestational age, length at birth, and gender (odds ratio, 6.10 and 95% CI, 1.15-32.57). No associations were found for maternal alcohol consumption during pregnancy, maternal smoking, or smoking by other people at home or presence of obstetric variables (e.g., gestational diabetes, preeclampsia, and abruptio placentae). The present study supports the hypothesis that high birth weight is an independent risk factor for childhood Wilms tumor, leukemia, and non-Hodgkin lymphoma. Further studies should explore biological reasons to explain this relationship and, ultimately, to expand our knowledge about prenatal influences on the occurrence of this disease. (AU)

FAPESP's process: 07/58044-2 - Birth weight and cardiovascular diseases: characterization of risk and genetic factors interrelation by identifying genomic imprinting mechanisms as well as genetic polymorphisms in homocysteine and eNOS pathways
Grantee:Maria Do Carmo Pinho Franco
Support Opportunities: Research Grants - Young Investigators Grants